Healthy Regulatory T (TReg) Cells
Regulatory T (TReg) cells are essential for suppressing immune cells.
They maintain immune tolerance to prevent autoimmune and inflammatory diseases
Dysfunctional Regulatory T (TReg) Cells
Dysregulation of IL-2 receptor signaling is linked to dysfunctional Tregs
Dysfunctional Tregs contribute to autoimmune diseases through:
- Failure to suppress other immune cells
- Loss of self-tolerance
- Lack of proper co-stimulation / downregulation of their suppressive mechanisms
TRegRx has developed a novel protein-drug conjugate (PDC) platform that repairs defective IL-2 receptor (IL-2R) signaling in Tregs, restoring immune balance without broad immunosuppression.
TRegRx is advancing its Protein Drug Conjugate (PDC) platform toward preclinical IND-enabling studies with the goal of entering first-in-human trials in type 1 diabetes, multiple sclerosis, and systemic lupus erythematosus, followed by additional programs in rheumatoid arthritis, inflammatory bowel disease and severe asthma.